I only ever go KDE.
But Gnome is good too. It seams to use less recourses and its interface is more simple. Basically less options which helps the average user out.
When KDE 4.0 came out i almost stopped using it. But it has gotten a lot better.
When using VNC I will got xfce. Love that sucker. Debating using it for my workstation desktop because my computer is crappy at work and kinda what something faster. Then again i rarely use VNC. I mean ssh with X11Forwarding does the trick.
But in the end I always say "If it ain't broke dont fix it." KDE works for me and I will keep using it till it stops.