Re: johnvanvliet's reply (Captain Beefheart anybody?).
I totally disagree. I have been running CentOS (and now Scientific Linux) for 4 years, doing a LOT of audio and video production and playing. Yes, getting everything right is sometimes not trivial (much easier with 6.x), but I have never had a problem with it making the system go fubar. I run VLC and Kaffeine extensively, along with Audacity and Cinelerra without problems. This is the system I use daily for a lot of heavy lifting - 64bit, 8 cores, 8GB, 15+TB disc, 1 or more virtual machines running, audio streaming, hard-core development work such as kernel drivers, network and embedded systems, debugging (both local and cross-platform on an ARM development board), and the usual business applications a consultant needs (time tracking, billing, word processing). The system only goes down when I have to install a new kernel or updated nVidia video driver.
FWIW, right now I have a Windows XP VM running, vlc streaming local npr jazz station, kaffeine running (paused) a video, chrome browser, system monitor, command line terminal, and the usual assortment of tools and utilities - a light load for me. No glitches whatsoever. Everything is patched up-to-date.