The whole reason that I tried Mepis is because of the "Mepis Magic," that is, the automatic hardware detection. I've tried many different Linux OS's and had to configure hardware, and I did not want to do this again. Anyway, I create a live USB (http://www.linuxliveusb.com), give it a go, and my WI-FI, webcam, and mic were all non-existent with Mepis. I was using an Averatec Buddy netbook with no propriotery drivers (no Broadcom, Nvidia, etc). I'm not sure why it didn't work, but it didn't. I had the same problems with antiX, the micro-Mepis distro.
All that said, I did like that Mepis was using KDE 3.5, though I think it will be better when they upgrade to KDE 4. The OS is nicely equipped with software, and it is easy to navigate.