You can use Wine for that purpose. but it only works on .net 2.0 / 3.0, Most probably, .net 4 is beyond the capacity right now. Ur best bet is for .net support on Linux is MONO. Mono has quite good capacity for much of the .net framework. May be the two references help U !
Mono Getting Start: www.mono-project.com/Start and
Compatibilities: www.mono-project.com/Compatibility

Thanks

The short answer is
" you do not "
the patented and copyrighted
"Microsoft .NET framework "
runs on Windows OS's

now there is a linux port of C# called "mono"
it is about 4 versions BEHIND the Microsoft .net .
It only just almost works .

if you NEED "Microsoft .NET framework "
run it on a Microsoft Operating System

Have a look at the mono project

Strictly speaking no. But you can use Mono (http://www.mono-project.com), which is an open source implementation of Microsoft's .NET Framework.